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There are many tests that health professionals may undertake prior to your diagnosis; the most common would be a chest x-ray to determine evidence of Sarcoidosis.
On a formal diagnosis regular tests will be performed to monitor the disease.
Currently the medical profession undertake a variety of tests not specific or uniform and it may depend on the consultant as to what tests are performed.
There is a range of medication available to manage the disease and symptoms many of which have side affects. It is therefore advised that you communicate with your consultant on available treatment to provide you with an option.
The doctor will look for symptoms of the disease, such as red bumps on the skin, swollen lymph nodes or redness in the eyes. The doctor also will check for other possible causes of any symptoms.
A chest x-ray, which poses little risk to health, can detect Sarcoidosis. X-ray beams cannot pass as easily through scarred tissue as through normal tissue. The x-ray may show Granulomas, which appear as a shadow, or enlarged lymph glands in the chest. Frequently, Sarcoidosis is diagnosed because a chest x-ray, taken routinely or for some other reason, shows an abnormality.
A staging system is used to classify chest x-rays taken to detect Sarcoidosis:
To view what the Lungs look like in a chest X-Ray click here.
X-ray stages do not tell the severity of the disease. However, in general the higher the stage of the x-ray, the worse the person's symptoms and lung function. There is a lot of individual variation and persons at Stages 1 through 4 may or may not have symptoms.
Blood analyses evaluate the number and types of blood cells in the body. The test measures the blood levels of various proteins, such as Angiotensin Converting Enzyme (ACE), which are known to be involved in immunological activities, as well as increases in calcium levels. However, ACE levels are not always elevated in those with the disease.
Blood tests can also show liver, kidney and bone marrow abnormalities that can occur with Sarcoidosis.
Pulmonary Function Tests
Pulmonary function tests are used to monitor the course of the disease in the lungs. These tests are safe and easy to do, but are frequently expensive. The results are compared over time.
One pulmonary function test uses a device that measures how much and how fast a person can blow air out of the lungs after taking a deep breath. This amount will be less than normal if there is significant inflammation and/or scarring (or fibrosis) in the lung.
Another test measures lung volume, which indicates how much air the lungs can hold. In some patients the lungs may shrink or contract due to Sarcoidosis and the lung volumes will be smaller than normal.
Other tests check for diffusing capacity or how well a gas moves into the bloodstream from the lungs. Sarcoidosis makes it harder for oxygen to move from the lungs into the bloodstream.
In one test, a device called a pulse oximeter is placed on the finger to give the doctor a rough idea of the level of oxygen in the patient’s blood.
An arterial blood gas test is a more accurate way to check the level of oxygen in the bloodstream. Blood from an artery is used because it has passed through the lungs and taken up oxygen. The blood is then analysed for its oxygen and carbon dioxide levels. The better the lungs are working, the more oxygen there will be in the arterial blood.
Fibre optic Bronchoscope:
In this procedure, a long, narrow, flexible tube with a light at the end is inserted into an airway of the lung. This makes it possible for the doctor to look at the tissue lining the air passageways of the lungs.
Fibre optic Bronchoscopy Biopsy:
In this procedure, a tiny sample of lung tissue is removed. The procedure is usually done to make the diagnosis when pulmonary function tests or chest x-rays are abnormal and characteristic of Sarcoidosis. If performed, it is done at the time of a fibre optic Bronchoscopy.
The test is done while the patient is awake but slightly sedated. The test is usually very safe and done on an outpatient basis.
Often, a procedure called a Bronchoalveolar Lavage (BAL) is done as part of a fibre optic bronchoscopy. BAL involves injecting saline (salt water) into a region of the lung. The fibre optic bronchoscope then uses suction to remove the fluid, which has washed out cells and other materials from the tiny air sacs (or alveoli) of the lung.
The pulmonary inflammation associated with Sarcoidosis begins in the lung in these air sacs. The removed sample is examined for signs of inflammation and tested for infections that may mimic Sarcoidosis.
A computed tomographic (CT) scan is a complicated kind of x-ray that gives a better picture of the lungs than the ordinary chest x-ray. A CT scan may be done to assess in more detail how much of the lung is affected by Sarcoidosis.
CT scans are not done routinely because they are more costly. Instead, they are done when specific factors call for their need. CT scan of the lungs is important if the patient is coughing up blood.
Magnetic resonance or magnetic resonance imaging, MRI. The test is not invasive and has no known hazards. It can show if features typical of Sarcoidosis are present in organs, particularly the brain and spinal cord.
Thallium and Gallium Scan:
These scans are used to help diagnose Sarcoidosis and are often done to check for cardiac sarcoidosis. Thallium and gallium are radioactive elements. The doctor injects one of these into a vein to help determine if the heart has been affected by Sarcoidosis. At a specified time after the injection, the body is scanned for radioactivity. Since any inflammation will cause an abnormal uptake of the radioactive element, the test does not give a definitive diagnosis of Sarcoidosis.
Positron emission tomography (PET) scanning detects changes in the body’s chemical activities. As with nuclear imaging tests, you are injected with a radioactive tracer, usually a kind of fluoride, before the test. It then travels through the bloodstream, accumulating in areas that show increased chemical activity. Since the parts of an organ that are not functioning properly often show increased chemical activity, PET scanning can help doctors determine whether an organ is healthy or inflamed. It is often used to help diagnose cardiac sarcoidosis or to find a good spot to biopsy.
In addition to the imaging techniques described above a number of other tests are sometimes used to help diagnose cardiac sarcoidosis. Electrocardiography and Holter monitoring are probably the simplest and most widely available tools for initial evaluations of your heart rhythm. Heart biopsies are invasive and are rarely used today to diagnose cardiac Sarcoidosis.
All persons diagnosed with Sarcoidosis should have an eye test done by an ophthalmologist (eye doctor), even if there are no symptoms of the disease in the eyes. If eye symptoms appear, the test will be repeated during treatment. Certain drugs can sometimes cause side effects related to vision. For the eye examination, the doctor looks into the eye for abnormalities.
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